Celiac Disease and Diabetes Melllitus
Description:
Celiac disease and TIDM both share common genetic patttern i,e sharing common HLA pattern including HLA-DQ2 and/or DQ8, TNF-α-308A. MYO9B polymorphism is also documented in both disorders.
Both diseases are immune-regulated and associated with autoimmune thyroiditis and rheumatoid arthritis.These diseases are associated with organ-specific autoantibodies: AIT with thyroid peroxidase (TPO) and thyroglobulin autoantibodies (TG), CD with endomysial (EMA) and transglutaminase (TTG) autoantibodies, and AD with adrenal autoantibodies.
Viral infections like rotavirus,coxsackievirus B etc cause disruption of intestinal permeability have also been documented to share role in both celiac disease and TIDM.Celiac disease associated with diabetes is usually silent, showing no signs and symptoms, such as abdominal pain, gas, bloating,malabsorption, weight loss, and abnormal liver function tests can be seen and easily confused with poor glucose control of TIDM.Untreated celiac disease can be associated with irregular blood glucose swings on screening.so it should be investigated.
Females have a higher risk of having both CD and T1DM than males.
Patients with CD and TIDM can show same symptoms like extremehunger,irritability
,weightloss,early fatigue,growth failure particularly in children.
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